Clinical Lecturer at the University of Edinburgh and Honorary Consultant at NHS Lothian. Roly's research and clinical interests lie with the inherited retinal dystrophies, both in terms of understanding disease mechanisms and identifying novel therapeutics.
After an extraordinary honours project in the lab, we have nabbed Fraser as research assistant extraordinaire. He continues to try to design new viral editing constructs which can be used in gene therapy for X-linked retinitis pigmentosa. He is particularly enthused by the versatility of genome editing therapy and how it can change the way we treat genetic diseases.
MRC HGU PhD candidate shared with the Boulter lab. Scott’s work looks to characterise the role of primary cilia in liver homeostasis and disease. In particular, focusing on understanding how primary cilia contribute in the transitions from healthy bile ducts to pre-malignant disease and from pre-malignant disease to cholangiocarcinoma (CCA).
Senior Investigator Scientist. Developing novel cilial biosensors and cilia specific proximity labeling animal models to investigate what happens to the ever-growing different types of cilia that are being uncovered during development and how are they affected in disease? What are the compositional changes on which these different types of cilia are built upon? Could we use this information to modulate the outcome of genetic diseases?
MRC PhD candidate, focusing on understanding the complex assembly of axonemal dynein proteins, the machines responsible for cilia movement. He also works on improving the ability of CRISPR/Cas9 editing technology to correct mutations in DNA for therapy.
Postdoctoral fellow. His current research focuses on developing new CRISPR-based therapies for rare genetic diseases, with an emphasis on primary ciliary dyskinesia (PCD). The ability of CRISPR to selectively and efficiently target any gene of our choosing has for the first time opened up the possibility of a truly personalised approach to treating genetic diseases.
Post-doctoral scientist. She is fascinated by how cilia detect and integrate diverse developmental signalling pathways. She is studying how ciliary dynamics are regulated at the whole organism level, currently by trying to understand how centriolar satellites detect extracellular signals and influence ciliogenesis.
ESRIC PhD candidate. Following her expertise in super-resolution imaging at EMBL, Tooba came to the MRC HGU use these high-end imaging methods to understand cilia dynamics. She has been developing new super-resolution methods to image cilia to understand the intraflagellar transport pathway in mammalian cells.
Biomedical Sciences Masters in Research candidate. Elena is developing genome editing-based strategies in our models of primary ciliary dyskinesia (PCD). She will be asking where and when genome editing events need to occur to be therapeutically beneficial.