LifeArc launches £40M research centres that will unlock new tests, treatments and cures for people living with rare diseases, including rare respiratory diseasese like primary ciliary dyskinesia, with the announcement of a LifeArc Centre for Rare Respiratory Diseases led by Edinburgh, Dundee, UCL, Southampton, Cambridge and Nottingham.
Read MoreOur ‘team science’ TUBB4B paper is published in Science!
Read MoreNew preprint from the lab on WGS for PCD diagnostics- power for novel gene identification and understanding and non-coding genome!
Read MoreCongratulations to the latest Mill lab graduate…. introducing Dr McPhie!
Read MoreWelcome to the team Dr Jana Muronova….
Read MoreA big welcome to Dr Marina Arbi…
Read MoreWelcome Chloe- our latest PhD candidate to join the team…
Read MoreScott’s thesis work on PLD is published, and on the cover…
Read MoreJoin us in Edinburgh for our UK Cilia Network Fall meeting- registration is now live! Free and open to all….
Read MoreWe are thrilled to be part of CILIAREN, one of 11 nodes in the MRC and NIHR joint-funded Rare Disease Research UK Platform…
Read MoreLimited epidemiology suggests broad genotype-phenotype relationships for several common PCD genes. For yet undetermined reasons, severe disease is associated with variants in some genes (e.g., CCDC39, CCDC40) and mild disease in others (e.g., DNAH9, RSPH1) . However, little is known about clinical features of patients with different variants in the same PCD gene. We use engineered mouse mutants and patients with variants in HEATR2/DNAAF5 to explore allele dosage effects for PCD genes for the first time. Read more….
Read MoreOur Nature Reviews Genetics review with Lotte Pedersen and Søren Chrtistiansen is out- how diveristy of signaling and cilia sturcture/function underlies clinical spectrum of the ciliopathies and what we still need to understand…
Read MoreThe cilia mechanosensation debate gets (bio)physical… we publish a Nature Reviews Nephrology News and Views on the latests as to whether cilia can function as mechanotransducers!
Read MorePostdoc Daniel Dodd wins a poster prize at CSHA CIlia and Centrosomes meeting in Awaji, Japan!
Read MoreHow the inherited retinal dystrophy causal gene RPGR regulates actin dynamics at the photoreceptor connecting cilium tip to allow disc formation necessary for vision.
Read MoreA tale of many tubulins…. how rare disease genetics has shed light into cilia diversity.
Read MoreFay Newton wins a Best Poster Prize at EMBO Cilia2022…
Read MoreWe are thrilled to announce our £3.7M MRC National Mouse Genetics Network cluster award on Congenital anomalies- patient-led functional genomics with an incredible team of experts from across the country including Prof. Karen Liu (KCL), Prof. Deborah Henderson (Newcastle), Prof. Nick Greene (ICH, UCL) and Dr. Steve Twigg (WIMM, Oxford).
Read MoreWe are thrilled to share our latest pre-print on how cilia loss (and cilia-dependent signaling) induces cell-autonomous circuits driving cyst formation in adult liver. No hedgehog involved….
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