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Senior research technician

The Mill lab is seeking to appoint a highly motivated and enthusiastic research technician with experience in mouse genetics. The candidate must have completed an undergraduate degree in genetics, cell biology, biochemistry or similar field. Knowledge of basic molecular and cell biology techniques (e.g. extensive knowledge of molecular cloning and sequencing, PCR, immunohistochemistry, microscopy, western blotting) is necessary. Experience in colony management, including phenotyping, genotyping and mouse husbandry is highly desirable, as is experience with eye phenotyping assays (e.g. use of a funduscope, electroretinogram), though not essential. The candidate will help generate strategies for assessing the molecular mechanisms of cell death in mouse models of human inherited eye disease. The successful candidate would be expected to work closely within a team consisting of clinicians and basic scientists.

This position is available on a fixed term basis for 12 months. Date closes 11/04/2019.

For informal enquiries contact Dr Roly Megaw.

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MRC funded 4yr PhD studentship in Human Genetics, Genomics and Disease

We are looking for enthusiastic and driven candidates to join us as one of 8 successful PhD intakes for 2019. It is a very multidisciplinary PhD programme encompassing high quality training, mentorship and research excellence to prepare you to tackle the most challenging questions underpinning health and disease. Importantly, it offers students the opportunity to participate participate in 3 mini-projects to experience different laboratory or computational environment, ahead of selecting their thesis project. There is also a structured teaching element covering key topics in areas such as genome regulation, disease mechanisms and biomedical genomics, plus computational and statistical training. Come join us! Second round of applications will close Friday 19th of April 2019.

Our studentship project this year is Defining cell-type specific molecular repair signatures during therapeutic genome editing. The recent game-changer for genetic disease is the utilization of CRISPR technology for human genome editing, thus offering a possible cure for genetic diseases. There are, however, sizeable obstacles to making this a therapeutic reality, including (a) targeted delivery of editing machinery and (b) improving repair efficiency. To fast-track solutions to these problems, we developed powerful fluorescent reporter mouse models, allowing sensitive read-outs of genome-editing. In this studentship, you will determine whether differences in DNA repair pathways exist in different cell types and/or at different stages of differentiation, and whether these change with different delivery systems. You will help determine the most effective formulation for establishing therapeutically-beneficial editing in vivo. Contact us if you’d like to discuss it more.